Electron micrograph: From Robert E Schmidt MD Electron micrograph: From Robert E Schmidt MD Electron micrograph: From Robert E Schmidt MD Myelin Degradation to Lipids Electron micrograph: From Robert E Schmidt MD Myelin Degradation to Lipids Electron micrograph: From Robert E Schmidt MD Electron micrograph: From Robert E Schmidt MD From R E Schmidt MD From R E Schmidt MD Macrophages Perivascular Contents Lipid droplets Myelin debris small Location In & around vessel... Macrophages, Perivascular Contents Lipid droplets Myelin debris, small Location In & around vessel... Macrophages Perivascular Contents Lipid droplets Myelin debris small Location In & around vessel... Macrophages, Perivascular Contents Lipid droplets Myelin debris, small Location In & around vessel... From R E Schmidt MD Denervated Schwann cell bands (Bands of Bungner) Due to: Myelinated axon loss... From R E Schmidt MD Denervated Schwann cell bands (Bands of Bungner) Due to: Myelinated axon loss... Macrophages Perivascular Contents Lipid droplets Myelin debris small Location In & around vessel... Macrophages, Perivascular Contents Lipid droplets Myelin debris, small Location In & around vessel... From R E Schmidt MD Axons Regenerating Surrounded by Schwann cell cytoplasm Unmyelinated Thinly... From R E Schmidt MD Axons, Regenerating Surrounded by Schwann cell cytoplasm Unmyelinated Thinly... Phagocytes (vacuolated) in endoneurium Large cells: Contain myelin debris or round clear lipid... Phagocytes (vacuolated) in endoneurium Large cells: Contain myelin debris or round, clear lipid... VvG stain Wallerian degeneration 5 Pathology Stages Axon degeneration & loss Myelin fragmentation... VvG stain Wallerian degeneration 5 Pathology Stages Axon degeneration & loss Myelin fragmentation... Acid phosphatase stain Phagocytic cells Endoneurial Acid phosphatase stain Phagocytic cells, Endoneurial Figure 3. Dose-dependence of axon protection by the Wld gene. ( a ) Top western blot showing the... Figure 3. Dose-dependence of axon protection by the Wld gene. ( a ) Top, western blot showing the... Phagocytes (vacuolated) in endoneurium Large cells: Contain myelin debris or round clear lipid... Phagocytes (vacuolated) in endoneurium Large cells: Contain myelin debris or round, clear lipid... Lipid droplets in Schwann Cells & Macrophages Closely-apposed Schwann cells (Dark arrows) &... Lipid droplets in Schwann Cells & Macrophages Closely-apposed Schwann cells (Dark arrows) &... Electron micrograph: From Robert E Schmidt MD Early phase: Schwann cell Myelin compact:... Electron micrograph: From Robert E Schmidt MD Early phase: Schwann cell Myelin, compact:... Cerebral infarctions can be accompanied by Wallerian degeneration of descending corticospinal tracts... Cerebral infarctions can be accompanied by Wallerian degeneration of descending corticospinal tracts... Figure 4. Axon protection 10−14 days after transection. ( a ) Western blot showing the extent of... Figure 4. Axon protection 10−14 days after transection. ( a ) Western blot showing the extent of... Waller Wallerian degeneration: Principles & Features Wallerian degeneration: Definition Sequence of... Waller Wallerian degeneration: Principles & Features Wallerian degeneration: Definition Sequence of... Figure 6. NAD + metabolism in Wld S brain. ( a ) Increased Nmnat activity and ( b ) unaltered NAD +... Figure 6. NAD + metabolism in Wld S brain. ( a ) Increased Nmnat activity and ( b ) unaltered NAD +... Waller Wallerian degeneration: Principles & Features Wallerian degeneration: Definition Sequence of... Waller Wallerian degeneration: Principles & Features Wallerian degeneration: Definition Sequence of... Supplementary Figure 2 ( jpg 1.2MB) The transgene construct and evidence for genomic integration. (... Supplementary Figure 2 ( jpg 1.2MB) The transgene construct and evidence for genomic integration. (... Oppenheim 1894 Wallerian degeneration: Pathology Hypoglossal nerve: 5 days after nerve section Oppenheim 1894 Wallerian degeneration: Pathology Hypoglossal nerve: 5 days after nerve section Axons: Degeneration Histology Morphology Axons: Degeneration Histology Morphology Toluidine blue stain Toluidine blue stain Supplementary Figure 3 ( jpg 337K) Wld protein is not detectable in axons of sciatic nerve ( a )... Supplementary Figure 3 ( jpg 337K) Wld protein is not detectable in axons of sciatic nerve ( a )... Figure 11. The cerebral angiogram of an 87-year-old man with acute onset left hemiplegia. The right... Figure 11. The cerebral angiogram of an 87-year-old man with acute onset left hemiplegia. The right... Supplementary Figure 1 ( jpg 223K) Higher magnification of preserved axon ultrastructure in distal... Supplementary Figure 1 ( jpg 223K) Higher magnification of preserved axon ultrastructure in distal... Electron micrograph: From Robert E Schmidt MD Electron micrograph: From Robert E Schmidt MD From: Robert Schmidt MD From: Robert Schmidt MD
Next »
Advanced Search