Molecular Diagnostics in Spinocerebellar ataxia Type 2 Molecular Diagnostics in Spinocerebellar ataxia Type 2 Figure 3. SCA1 neuropathology is improved by shRNAs directed to ataxin-1. ( a ) SCA and wild-type... Figure 3. SCA1 neuropathology is improved by shRNAs directed to ataxin-1. ( a ) SCA and wild-type... Figure 1. Silencing ataxin-1. ( a ) Cartoon of the ataxin-1 cDNA and regions tested for silencing... Figure 1. Silencing ataxin-1. ( a ) Cartoon of the ataxin-1 cDNA and regions tested for silencing... Figure 5. Sca10 is widely expressed in brain regions that are anatomical substrates for ataxia and... Figure 5. Sca10 is widely expressed in brain regions that are anatomical substrates for ataxia and... v   •   d   •   e Pathology : hematology myeloid hematologic disease (primarily ... v   •   d   •   e Pathology : hematology , myeloid hematologic disease (primarily ... ( Figure 1. Tsuda et al . demonstrate homologous pathways that mediate ataxin-1–induced... ( Figure 1. Tsuda et al . demonstrate homologous pathways that mediate ataxin-1–induced... Figure 1. Expansion mutations in four SCA10 families. a Pedigrees of the four families studied for... Figure 1. Expansion mutations in four SCA10 families. a , Pedigrees of the four families studied for... Figure 1. Clinical findings and haplotype analysis. a b A T1-weighted magnetic resonance imaging... Figure 1. Clinical findings and haplotype analysis. a , b , A T1-weighted magnetic resonance imaging... Figure 4. Correlation between the size of expanded SCA10 ATTCT repeat and the age of onset. A... Figure 4. Correlation between the size of expanded SCA10 ATTCT repeat and the age of onset. A... Figure 3. The physical map of the ATTCT pentanucleotide repeat region. a A schematic presentation... Figure 3. The physical map of the ATTCT pentanucleotide repeat region. a , A schematic presentation... Figure 1. BAC expansion and control constructs. ( a ) Diagram of control BAC (BAC-Ctl) and modified... Figure 1. BAC expansion and control constructs. ( a ) Diagram of control BAC (BAC-Ctl) and modified... Figure 1 : AFG3L2 mutations cause amino acid substitutions in highly conserved regions of the... Figure 1 : AFG3L2 mutations cause amino acid substitutions in highly conserved regions of the... Figure 4. Model of the resolution of stalled covalent topoisomerase I−DNA complexes that result in... Figure 4. Model of the resolution of stalled covalent topoisomerase I−DNA complexes that result in... Very short stocky and solid build. Very short, stocky and solid build. Next Next Figure 1. RAPID cloning of the SCA8 expanded CTG repeat. a 2D-RED analysis of Eco RI-digested... Figure 1. RAPID cloning of the SCA8 expanded CTG repeat. a , 2D-RED analysis of Eco RI-digested... Figure 2. Physical map of 14q23−q32 and molecular analyses of TDP1 . a Physical map of the... Figure 2. Physical map of 14q23−q32 and molecular analyses of TDP1 . a , Physical map of the... The principal sites of neuronal loss and organ dysfunction in Spinocerebellar ataxia 1 (SCA1) SCA2... The principal sites of neuronal loss and organ dysfunction in Spinocerebellar ataxia 1 (SCA1), SCA2,... Figure 2. Large SCA8 kindred. Filled symbols indicate individuals with ataxia symbols with a dot... Figure 2. Large SCA8 kindred. Filled symbols indicate individuals with ataxia, symbols with a dot... ...upon myotonic dystrophy fragile X Spinocerebellar ataxia type 7 and Huntington's disease loci. ...upon myotonic dystrophy, fragile X, Spinocerebellar ataxia type 7, and Huntington's disease loci. ...upon myotonic dystrophy fragile X Spinocerebellar ataxia type 7 and Huntington's disease loci. ...upon myotonic dystrophy, fragile X, Spinocerebellar ataxia type 7, and Huntington's disease loci. ...upon myotonic dystrophy fragile X Spinocerebellar ataxia type 7 and Huntington's disease loci. ...upon myotonic dystrophy, fragile X, Spinocerebellar ataxia type 7, and Huntington's disease loci. ...upon myotonic dystrophy fragile X Spinocerebellar ataxia type 7 and Huntington's disease loci. ...upon myotonic dystrophy, fragile X, Spinocerebellar ataxia type 7, and Huntington's disease loci. ...upon myotonic dystrophy fragile X Spinocerebellar ataxia type 7 and Huntington's disease loci. ...upon myotonic dystrophy, fragile X, Spinocerebellar ataxia type 7, and Huntington's disease loci.
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