Structure of human PSAP, saposins, and sequence alignment of a known neurotrophic fragment of human...Joshua Black Joshua has a diagnosis of Metachromaticleukodystrophy. LeukodystrophyBetween CDH23 (cadherin-like 23; centromeric) and Carbohydrate (chondroitin 6) sulfotransferase 3...Figure 1. The MLD gene therapy model. a , Histopathology of MLD mouse brain. Transverse semi-thin...Figure 5. Reconstitution of ARSA activity in the brains of MLD mice. The brain of an As2 -/- mouse,...Figure 4. The therapeutic activity of ARSA gene transfer extends to the uninjected, contralateral...Figure 6. Long-term protection from learning impairment, neuronal damage and lipid storage in MLD...This image shows part of a coronal section; the ventricle is seen at the bottom. Pale areas in the...Close windowA：リピドーシス＆ロイコジストロフィー Metachromaticleukodystrophy（異染性白質ジストロフィー[MLD]) Krabbe病（クラッペ病） Multiple...Dysmyelination MLD Links: OMIM: 250100 Metachromaticleukodystrophy OMIM: Clinical Synopsis OMIM:...Having fun!